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The biphasic effect of CBD

Have you ever shared a coffee with a friend and watched them become alert and wide awake while you felt tired and drowsy?

Food and supplements can affect different people in different ways. Everyone is individual and as some nutrients or chemicals reach your bloodstream they interact with your cells and tissues in a way that is unique to you. Differences can be due to body composition or the amount of the substance used.

Cannabidiol (CBD) works by boosting your body’s ability to send signals across its systems (Zou & Kumar, 2018). These chemical messages restore balance and promote a healthy state. Because these interactions can be complicated, how it works and the amount you need depends on your own body’s makeup.

When you increase the amount of CBD you take you may notice a change in effect. This is due to the biphasic nature of CBD. To find out how you can benefit from this quality let’s first explore what biphasic means.

What is the biphasic effect?

A biphasic effect is when one substance acts in two different ways as the concentration increases. When you drink a small amount of alcohol it gives an uplifting and stimulating effect. However, if you drink more and it passes a level of 0.05% in your bloodstream, it becomes a depressant and can make you subdued and tired (CBD Oil Review, 2018).

There is growing evidence from scientific studies and user reports that CBD produces a biphasic effect. This effect is one of the many things that makes it so useful. In low measures, these studies suggest that its general effects make it suitable for use as a day time supplement. When taken in higher amounts it is more suitable to be taken in the evening. (Babson, Sottile & Morabito., 2017).

For a long time, it has been acknowledged that the amount of CBD used is critical to the research. In 2008, Antonio Zuardi, Professor of the School of Medicin eat the University of Sao Paulo, was aware that the actions of CBD could be plotted as a bell curve, becoming more effective when specific amounts were in the bloodstream. “It is important to highlight that…the [amount] is a pivotal factor in CBD research.”

This effect has become a crucial factor for consumers and manufacturers even include references to it in product directions. For example, some hemp teas suggest that brewing them for a short time is good for daytime use and a longer brew works well for the evening.

How does it work for me?

While studies often use a standard amount for all participants, the effect of CBD depends on several factors that are unique to you. They include body mass, tolerance and chemical makeup.

An amount that has a small effect on one person could be the same as one that has a large effect on someone else. Finding the effective amount for you is an important part of using CBD regularly.

To explore this, start low and go slow. Begin with the minimum amount recommended on the product label and take it regularly for one to two weeks. After that, make a small increase every three to seven days.

For example, if your oil recommends you start with two drops two times a day:

Week 1: 2 drops, 2 times a day
Week 2: 2 drops, 2 times a day
Week 3: 3 drops, 2 times a day
Week 4: 4 drops, 2 times a day

This will let you find an effective low amount for morning and daytime use and a higher volume for the evening.


CBD is an effective way to support your health and wellbeing. While there is no standard amount to suit everybody, taking the time to find your own suitable volume is well worth it in the long run

Small regular amounts are a great way to take it during the day. Larger volumes are more suited to the evening. Building up slowly is an excellent way to get used to its effect and create a personal routine that benefits from each effect.

References on the Biphasic Effect of CBD

CBD Oil Review. (2018) The biphasic properties of CBD. Retrieved from
Hope CBD. (August 11, 2017). The biphasic properties of cannabis. Retrieved from
Moore, M. (July 6, 2018). How the Biphasic Effect of Cannabinoids Controls Dosing. Retrieved from
Murillo-Rodriguez, E. et al. (May, 2014). Potential effects of cannabidiol as a wake-promoting agent. Retrieved from
Rey, A. et al. (November, 2012). Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. Retrieved from
Wallace, M. et al. (November 2007). Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. Retrieved from
Zou, S & Kumar, U. (March 19, 2018). Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Retrieved from
Zuardi, A. (September, 2008). Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Retrieved from

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